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1

Robustaflavone, a naturally occurring biflavanoid, is a potent non-nucleoside inhibitor of hepatitis B virus replication in vitro

Yuh-Meei Lin, David E Zembower, Michael T Flavin, Ralph M Schure, Herbert M Anderson, Brent E Korba, Fa-Ching Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 228 KB

english, 1997

2

Nitazoxanide is an Effective Antiviral Agent Against Both HBV and HCV replication in vitro

Brent Korba, Muller Abigail, Ayers Marc, Jean-François Rossignol

Journal:

Antiviral Research

Year:

2007

Language:

english

File:

PDF, 60 KB

english, 2007

3

Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication

Brent E. Korba, Abigail B. Montero, Kristine Farrar, Karen Gaye, Sampa Mukerjee, Marc S. Ayers, Jean-François Rossignol

Journal:

Antiviral Research

Year:

2008

Language:

english

File:

PDF, 500 KB

english, 2008

4

ChemInform Abstract: Synthesis and Antiviral Activity of Cyclopropyl-Spirocarbocyclic Adenosine, (4R,5S,6R,7R)-4-(6-Amino-9H-purin-9-yl)-7-(hydroxymethyl)spiro [2.4]heptane-5,6-diol Against Hepatitis C Virus.

Srinivas Gadthula, Ravindra K. Rawal, Ashoke Sharon, Dong Wu, Brent Korba, Chung K. Chu

Journal:

Year:

2011

File:

PDF, 40 KB

2011

5

Hepatocellular carcinoma in woodchuck hepatitis virus-infected woodchucks: Presence of viral DNA in tumor tissue from chronic carriers and animals serologically recovered from acute infections

Dr. Brent E. Korba, Frances V. Wells, Betty Baldwin, Paul J. Cote, Bud C. Tennant, Hans Popper, John L. Gerin

Journal:

Year:

1989

Language:

english

File:

PDF, 1.16 MB

english, 1989

6

Hepatocellular carcinoma in Richardson's ground squirrels (Spermophilus richardsonii): Evidence for association with hepatitis B–like virus infection

Dr. Bud C. Tennant, N. Mrosovsky, Kirsteen McLean, Paul J. Cote, Brent E. Korba, Ronald E. Engle, John L. Gerin, Janet Wright, Gail R. Michener, Elizabeth Uhl, John M. King

Journal:

Year:

1991

Language:

english

File:

PDF, 1001 KB

english, 1991

7

Identification of HBV DNA sequences that are predictive of response to lamivudine therapy

Alessia Ciancio, Antonina Smedile, Mario Rizzetto, Marco Lagget, John Gerin, Brent Korba

Journal:

Year:

2004

Language:

english

File:

PDF, 135 KB

english, 2004

8

Integration of woodchuck hepatitis and N-myc rearrangement determine size and histologic grade of hepatic tumors

James R. Jacob, Agnes Sterczer, Ilia A. Toshkov, Amy E. Yeager, Brent E. Korba, Paul J. Cote, Marie-Annick Buendia, John L. Gerin, Bud C. Tennant

Journal:

Year:

2004

Language:

english

File:

PDF, 576 KB

english, 2004

9

Effects of age and viral determinants on chronicity as an outcome of experimental woodchuck hepatitis virus infection

Paul J. Cote, Brent E. Korba, Roger H. Miller, James R. Jacob, Betty H. Baldwin, William E. Hornbuckle, Robert H. Purcell, Bud C. Tennant, John L. Gerin

Journal:

Year:

2000

Language:

english

File:

PDF, 164 KB

english, 2000

10

Direct modulation of HBV surface antigen in a human, HBsAg-producing hepatocellular carcinoma cell line by alpha, beta, or gamma interferons

Brent E. Korba, Dr. Demetris Boumpas, Dean Mann, Dr. George H. Yoakum

Journal:

Journal of Medical Virology

Year:

1990

Language:

english

File:

PDF, 557 KB

english, 1990

11

Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs

John E. Coughlin, Seetharamaiyer Padmanabhan, Guangrong Zhang, Cassandra J. Kirk, Chandrika P. Govardhan, Brent E. Korba, Kathleen O’Loughlin, Carol E. Green, Jon Mirsalis, John D. Morrey, Radhakrishn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 483 KB

english, 2010

12

Corrigendum to “Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine” [Bioorg. Med. Chem. 16 (2008) 2148–2155]

Chengwei Li, Mark N. Prichard, Brent E. Korba, John C. Drach, Jiri Zemlicka

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 116 KB

english, 2009

13

Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine

Chengwei Li, Mark N. Prichard, Brent E. Korba, John C. Drach, Jiri Zemlicka

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 206 KB

english, 2008

14

Synthesis and in vitro anti-hepatitis B and C virus activities of ring-expanded (‘fat’) nucleobase analogues containing the imidazo[4,5-e][1,3]diazepine-4,8-dione ring system

Peng Zhang, Ning Zhang, Brent E. Korba, Ramachandra S. Hosmane

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 124 KB

english, 2005

15

Structure–activity relationship studies on anti-HCV activity of ring-expanded (‘fat’) nucleobase analogues containing the imidazo[4,5-e][1,3]diazepine-4,8-dione ring system

Peng Zhang, Ning Zhang, Brent E. Korba, Ramachandra S. Hosmane

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 145 KB

english, 2007

16

Synthesis and antiviral activity of cyclopropyl-spirocarbocyclic adenosine, (4R,5S,6R,7R)-4-(6-amino-9H-purin-9-yl)-7-(hydroxymethyl)spiro[2.4]heptane-5,6-diol against hepatitis C virus

Srinivas Gadthula, Ravindra K. Rawal, Ashoke Sharon, Dong Wu, Brent Korba, Chung K. Chu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 404 KB

english, 2011

17

Parallel solid-phase synthesis of nucleoside phosphoramidate libraries

Yi Jin, Xiaoling Chen, Marie-Eve Côté, Arlène Roland, Brent Korba, Samir Mounir, Radhakrishnan P Iyer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 148 KB

english, 2001

18

Discovery of imidazo[1,2-c]pyrimidin-5(6H)-one heterosubstituted nucleoside analogues with potent activity against human hepatitis B virus in vitro

Tarek S. Mansour, Colleen A. Evans, Marie Charron, Brent E. Korba

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 287 KB

english, 1997

19

The Importance of the 4′-Hydroxyl Hydrogen for the Anti-trypanosomal and Antiviral Properties of (+)-5′-Noraristeromycin and Two 7-Deaza Analogues

Katherine L. Seley, Stewart W. Schneller, Erik De Clercq, Donna Rattendi, Schenella Lane, Cyrus J. Bacchi, Brent Korba

Journal:

Bioorganic & Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 126 KB

english, 1998

20

Treatment of chronic hepadnavirus infection in a woodchuck animal model with an inhibitor of protein folding and trafficking

Block, Timothy M., Lu, Xuanyong, Mehta, Anand S., Blumberg, Baruch S., Tennant, Bud, Ebling, Mathew, Korba, Brent, Lansky, David M., Jacob, Gary S., Dwek, Raymond A.

Journal:

Nature Medicine

Year:

1998

File:

PDF, 1.37 MB

1998

21

Treatment of chronic woodchuck hepatitis virus infection in the eastern woodchuck (marmota monax) with nucleoside analogues is predictive of therapy for chronic hepatitis B virus infection in humans

Brent E. Korba, Paul Cote, William Hornbuckle, Bud C. Tennant, John L. Gerin

Journal:

Year:

2000

Language:

english

File:

PDF, 314 KB

english, 2000

22

Temporal Pathogenesis of Experimental Neonatal Woodchuck Hepatitis Virus Infection: Increased Initial Viral Load and Decreased Severity of Acute Hepatitis During the Development of Chronic Viral Infection

Paul J Cote, Ilia Toshkov, Christine Bellezza, Mary Ascenzi, Carol Roneker, Lou Ann Graham, Betty H Baldwin, Karen Gaye, Ikuo Nakamura, Brent E Korba, Bud C Tennant, John L Gerin

Journal:

Year:

2000

Language:

english

File:

PDF, 799 KB

english, 2000

23

Antiviral activity of clevudine [L-FMAU, (1-(2-fluoro-5-methyl-β, L-arabinofuranosyl) uracil)] against woodchuck hepatitis virus replication and gene expression in chronically infected woodchucks (Marmota monax)

Simon F. Peek, Paul J. Cote, James R. Jacob, Ilia A. Toshkov, William E. Hornbuckle, Betty H. Baldwin, Frances V. Wells, C.K. Chu, John L. Gerin, Bud C. Tennant, Brent E. Korba

Journal:

Year:

2001

Language:

english

File:

PDF, 471 KB

english, 2001

24

Phosphatidyl-2′,3′-dideoxy-3′-thiacytidine: synthesis and antiviral activity in hepatitis B- and HIV-1-infected cells

Hong Xie, Michael Voronkov, Dennis C. Liotta, Brent A. Korba, Raymond F. Schinazi, Douglas D. Richman, Karl Y. Hostetler

Journal:

Antiviral Research

Year:

1995

Language:

english

File:

PDF, 435 KB

english, 1995

25

Antisense oligonucleotides are effective inhibitors of hepatitis B virus replication in vitro

Brent E. Korba, John L. Gerin

Journal:

Antiviral Research

Year:

1995

Language:

english

File:

PDF, 1007 KB

english, 1995

26

In vitro evaluation of combination therapies against hepatitis B virus replication

Journal:

Antiviral Research

Year:

1996

Language:

english

File:

PDF, 231 KB

english, 1996

27

Suppression of lamivudine-resistant B-domain mutants by adefovir dipivoxil in the woodchuck hepatitis virus model

James R Jacob, Brent E Korba, Paul J Cote, Ilia Toshkov, William E Delaney IV, John L Gerin, Bud C Tennant

Journal:

Antiviral Research

Year:

2004

Language:

english

File:

PDF, 111 KB

english, 2004

28

Enhancement of antiviral activity against hepatitis C virus in vitro by interferon combination therapy

Chiaki Okuse, Jo Ann Rinaudo, Kristine Farrar, Frances Wells, Brent E. Korba

Journal:

Antiviral Research

Year:

2005

Language:

english

File:

PDF, 350 KB

english, 2005

29

Initial Pharmacodynamic Evaluation of Orally Bioavailable Prodrugs of SB-9000, a Novel Anti-HBV Agent

Radhakrishnan Iyer, Seetharamaiyer Padmanabhan, John Coughlin, Guangrong Zhang, Cassandra Kirk, Brent Korba, John Morrey

Journal:

Antiviral Research

Year:

2007

Language:

english

File:

PDF, 74 KB

english, 2007

30

shRNAs Targeting Hepatitis C: Effects of Sequence and Structural Features, and Comparison with siRNA

Brian Johnston, Alexander Vlassov, Brent Korba, Heini Ilves, Roger Kaspar, Sergei Kazakov, Kristine Farrar, Sampa Mukerjee, Attila Seyhan

Journal:

Antiviral Research

Year:

2007

Language:

english

File:

PDF, 69 KB

english, 2007

31

Optimization of shRNA Features for Targeting Hepatitis C Virus

Brian Johnston, Alexander Vlassov, Brent Korba, Kristine Farrar, Sampa Mukerjee, Attila Seyhan, Heini ILves, Roger Kaspar, Devin Leake, Sergei Kazakov, Qing Ge

Journal:

Antiviral Research

Year:

2008

Language:

english

File:

PDF, 72 KB

english, 2008

32

A Role for Nitazoxanide in Combination with STAT-C Agents for Inhibition of HCV Replication and the Potential for the Prevention of Viral Resistance

Brent Korba, Jeffery Glenn, Menashe Elazar, Jean-François Rossignol

Journal:

Antiviral Research

Year:

2009

Language:

english

File:

PDF, 76 KB

english, 2009

33

Activation of Retinoic Acid Inducible Gene (RIG-I) by Nucleotide Analogs: A Potential Novel Mechanism for Antiviral Discovery

Radhakrishnan Iyer, John Coughlin, Seetharamaiyer Padmanabhan, Brent Korba, Sua Myong

Journal:

Antiviral Research

Year:

2010

Language:

english

File:

PDF, 67 KB

english, 2010

34

Simvastatin potentiates the anti-hepatitis B virus activity of FDA-approved nucleoside analogue inhibitors in vitro

Ted Bader, Brent Korba

Journal:

Antiviral Research

Year:

2010

Language:

english

File:

PDF, 611 KB

english, 2010

35

Nucleotide Analogs that Induce Cellular Production of Antimicrobial Proteins

Radhakrishnan Iyer, John Coughlin, Seetharamaiyer Padmanabhan, Brent Korba, Sua Myong, Bud Tennant, John Morrey

Journal:

Antiviral Research

Year:

2010

Language:

english

File:

PDF, 80 KB

english, 2010

36

Orally Bioavailable Anti-HBV Dinucleotide Acyloxyalkyl Prodrugs

Radhakrishnan Iyer, John Coughlin, Cassandra Kirk, Seetharamaiyer Padmanabhan, Brent Korba, Kathleen O’Loughlin, Carol Green, Jon Mirsalis, John Morrey

Journal:

Antiviral Research

Year:

2010

Language:

english

File:

PDF, 67 KB

english, 2010

37

Synthesis of a Series of 2′-Modified Tricyclic Nucleosides as Potential HCV Agents

Matthew Tomney, Brent Korba, Sarah Zimmermann, Katherine Seley-Radtke

Journal:

Antiviral Research

Year:

2010

Language:

english

File:

PDF, 70 KB

english, 2010

38

Nitazoxanide is an Indirect Inhibitor of HCV Replication Through Modulation of Cellular Kinase CKI Alpha to Enhance HCV NS5A Hyperphosphorylation

Abigail Montero, Prasanth Viswanathan, Chansuek Yon, Brent Korba

Journal:

Antiviral Research

Year:

2011

Language:

english

File:

PDF, 120 KB

english, 2011

39

Mutations in HCV non-structural genes do not contribute to resistance to nitazoxanide in replicon-containing cells

Changsuek Yon, Prasanth Viswanathan, Jean-François Rossignol, Brent Korba

Journal:

Antiviral Research

Year:

2011

Language:

english

File:

PDF, 487 KB

english, 2011

40

Antiviral activity of novel 2′-fluoro-6′-methylene-carbocyclic adenosine against wild-type and drug-resistant hepatitis B virus mutants

Jianing Wang, Uma S. Singh, Ravindra K. Rawal, Massaya Sugiyama, Jakyung Yoo, Ashok K. Jha, Melissa Scroggin, Zhuhui Huang, Michael G. Murray, Rajgopal Govindarajan, Yasuhito Tanaka, Brent Korba, Chun

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 332 KB

english, 2011

41

Corrigendum to “Antiviral activity of novel 2′-fluoro-6′-methylene-carbocyclic adenosine against wild-type and drug-resistant hepatitis B virus mutants” [Bioorg. Med. Chem. Lett. 21 (2011) 6328–6331]

Jianing Wang, Uma S. Singh, Ravindra K. Rawal, Masaya Sugiyama, Jakyung Yoo, Ashok K. Jha, Melissa Scroggin, Zhuhui Huang, Michael G. Murray, Rajgopal Govindarajan, Yasuhito Tanaka, Brent Korba, Chung

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 117 KB

english, 2012

42

Corrigendum to “Enhanced antiviral benefit of combination therapy with lamivudine and famciclovir against WHV replication in chronic WHV carrier woodchucks”: [Antiviral Res. 45 (2000) 19–32]

Brent E Korba, Paul Cote, William Hornbuckle, Raymond Schinazi, John L Gerin, Bud C Tennant

Journal:

Antiviral Research

Year:

2000

Language:

english

File:

PDF, 124 KB

english, 2000

43

Novel ring-expanded nucleoside analogs exhibit potent and selective inhibition of hepatitis B virus replication in cultured human hepatoblastoma cells

Ramesh K Sood, Vishweshwar S Bhadti, Ali I Fattom, Robert B Naso, Brent E Korba, Earl R Kern, Huan-Ming Chen, Ramachandra S Hosmane

Journal:

Antiviral Research

Year:

2002

Language:

english

File:

PDF, 100 KB

english, 2002

44

Mutations in the conserved woodchuck hepatitis virus polymerase FLLA and YMDD regions conferring resistance to lamivudine

Kathleen M. Tatti, Brent E. Korba, Heather L. Stang, Simon Peek, John L. Gerin, Bud C. Tennant, Raymond F. Schinazi

Journal:

Antiviral Research

Year:

2002

Language:

english

File:

PDF, 133 KB

english, 2002

45

Robustaflavone, a potential non-nucleoside anti-hepatitis B agent

David E Zembower, Yuh-Meei Lin, Michael T Flavin, Fa-Ching Chen, Brent E Korba

Journal:

Antiviral Research

Year:

1998

Language:

english

File:

PDF, 146 KB

english, 1998

46

The S-acyl-2-thioethyl pronucleotide approach applied to acyclovir: Part I. Synthesis and in vitro anti-hepatitis B virus activity of bis(S-acyl-2-thioethyl)phosphotriester derivatives of acyclovir

Christian Périgaud, Gilles Gosselin, Jean-Luc Girardet, Brent E. Korba, Jean-Louis Imbach

Journal:

Antiviral Research

Year:

1999

Language:

english

File:

PDF, 196 KB

english, 1999

47

Utilization of transgenic mice replicating high levels of hepatitis B virus for antiviral evaluation of lamivudine

John D. Morrey, Kevin W. Bailey, Brent E. Korba, Robert W. Sidwell

Journal:

Antiviral Research

Year:

1999

Language:

english

File:

PDF, 226 KB

english, 1999

48

Enhanced antiviral benefit of combination therapy with lamivudine and famciclovir against WHV replication in chronic WHV carrier woodchucks

Brent E Korba, Paul Cote, William Hornbuckle, Raymond Schinazi, John L Gerin, Bud C Tennant

Journal:

Antiviral Research

Year:

2000

Language:

english

File:

PDF, 326 KB

english, 2000

49

Systemic distribution of woodchuck hepatitis virus in the tissues of experimentally infected woodchucks

Brent E. Korba, Eric J. Gowans, Frances V. Wells, Bud C. Tennant, Richard Clarke, John L. Gerin

Journal:

Year:

1988

Language:

english

File:

PDF, 921 KB

english, 1988

50

Nucleotide analogs as novel anti-hepatitis B virus agents

Radhakrishnan P Iyer, Seetharamaiyer Padmanabhan, Guangrong Zhang, John D Morrey, Brent E Korba

Journal:

Current Opinion in Pharmacology

Year:

2005

Language:

english

File:

PDF, 227 KB

english, 2005

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